Trans-Isthmian Route

From Spanish conquistadors to gold rush adventurers, on the Trans-Isthmian Route, you will find yourself in the most interesting historical journey in Panama. You will be traversing Panama from South to North by road, exploring the forts at San Lorenzo, admiring the Panama Canal Expansion project from the new Gatun Observation Center, and enjoying the Panama Railway train ride from Colon to Panama City on the return.